Rosenthal Center for Complementary & Alternative Medicine - Nov. 16, 2005: Research on DHEA for Depression in People with HIV/AIDS

The Rosenthal Center for Complementary and Alternative Medicine

Presents

DHEA for Depression

in people with HIV/AIDS

Judith Rabkin, Ph.D., M.P.H., and

Martin McElhiney, Ph.D.

will present results from their recent NIH-funded research

Wednesday Nov. 16, 2005

12:00 – 1:00 pm

(bring your lunch)

Merritt Conference Room

P&S 3-418, 630 W. 168^th Street [next to Student Affairs Office]

Speakers Judith Rabkin, Ph.D., M.P.H. is Professor of Clinical Psychology in Psychiatry, CU P&S

& Co-Investigators: Martin McElhiney, Ph.D. is Research Scientist, NY State Psychiatric Institute

Abstract : We conducted an 8-week double blind placebo controlled study, with extended treatment for DHEA responders, and open-label treatment for placebo non-responders. 145 patients with an Axis I non-major depressive disorder were randomized and 133 completed the trial. Dosing was flexible from 100 to 400 mg/day. Outcome was assessed using intention to treat analyses, confirmed by completer analysis. In the former, 56% of patients randomized to DHEA and 31% randomized to placebo were rated much or very much improved. Side effects were minimal, nor were significant changes in immunologic or virologic measures of immune status observed in either group.